Development of floating 3D-printed devices for carvedilol tablet
Author:
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Date:
2022
Publisher:
Trans Tech Publications Ltd
Abstract:
A floating drug delivery device is one type of gastro-retentive drug delivery system (GRDDS). Carvedilol (CAR) is poorly soluble in alkaline pH (intestinal environment) and has good solubility in the acidic pH (stomach environment). Hence, floating 3D-printed devices (FD) were developed from polylactic acid (PLA) filaments using fused deposition modeling (FDM) and designed to be a tablet shape with an anti-flip-up property as GRDDS of carvedilol tablets. There were two parts of FD, including the cap and the base. The base was designed with different hole diameters (2.5, 3.5, and 4.5 mm) for a controlled drug release. The FD had a smooth texture and white color. All the FD showed the anti-flip-up property. The drug release showed that the FD with 2.5- and 3.5-mm hole diameters had the potential to control the drug release. The CAR tablet-incorporated FD with a 3.5 mm hole diameter showed an optimal sustained-release profile, 99.8 % of drug release in 10 h. Moreover, zero-order kinetic was achieved. Therefore, this device may be promising to provide an extended drug release in the stomach.
Description:
Published in : Key Engineering Materials, Volume 914, p.45-51
Type:
Rights Holder:
มหาวิทยาลัยศิลปากร
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