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Vancomycin area under the curve and pharmacokinetic parameters during the first 24 Hours of treatment in critically ill patients using bayesian forecasting
Background
Currently, the achievement of the target area under the curve (AUC)/minimum inhibitory concentration ratio during the first 24 - 48 h of treatment is associated with reduced 30-day mortality and greater ...
Optimizing the dosing regimens of tigecycline against vancomycin- resistant enterococci in the treatment of intra-abdominal and skin and soft tissue infections
Tigecycline was previously considered to have activity against vancomycin-resistant Enterococcus (VRE) isolates, but the optimal dose was not clarified. Thus, this study assessed the in vitro activity of tigecycline against ...
Clinical Impact of Vancomycin Treatment in Ampicillin-Susceptible Enterococci Bloodstream Infections
Enterococci are major causes of bacteremia. Although the mortality rate of ampicillin- susceptible enterococci (ASE) bloodstream infections (BSI) is lower, compared with that of ampicillin-resistant enterococci BSI, the ...
Optimization of linezolid dosing regimens for treatment of vancomycin-resistant enterococci infection
Background: Linezolid, an oxazolidinone antibiotic, is recommended for vancomycin-resistant enterococci (VRE). However, 100% free-drug concentration above the minimum inhibitory concentration (fT>MIC) and an area under the ...