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Vancomycin-resistant enterococcal infection in a Thai university hospital: clinical characteristics, treatment outcomes, and synergistic effect
Purpose: The incidence of infections with vancomycin-resistant enterococci (VRE) is increasing, with associated high mortality rates and limited therapeutic choices. We investigated the clinical characteristics and treatment ...
Identification of blaOXA23 and blaNDM1 from Carbapenem- resistant Acinetobacter baumannii at a Private Hospital in Thailand
OBJECTIVES: This study aimed to detect carbapenemase genes and their clonal relationships among carbapenem-resistant Acinetobacter baumannii (CRAB) clinical isolates.
MATERIAL AND METHODS: Fifteen CRAB isolates were ...
Optimizing the dosing regimens of tigecycline against vancomycin- resistant enterococci in the treatment of intra-abdominal and skin and soft tissue infections
Tigecycline was previously considered to have activity against vancomycin-resistant Enterococcus (VRE) isolates, but the optimal dose was not clarified. Thus, this study assessed the in vitro activity of tigecycline against ...
Colistin plus sulbactam or fosfomycin against carbapenem-resistant acinetobacter baumannii: improved efficacy or decreased risk of nephrotoxicity?
Background
Acinetobacter baumannii has been recognized as a cause of nosocomial infection. To date, polymyxins, the last-resort therapeutic agents for carbapenem-resistant A. baumannii (CRAB). Thus, the small number of ...
The Synergistic activity and optimizing doses of tigecycline in combination with aminoglycosides against clinical carbapenem-resistant klebsiella pneumoniae isolates
Carbapenem-resistant Enterobacteriaceae (CRE), especially carbapenem-resistant Klebsiella pneumoniae (CRKP), are among the largest pathogenic threats to humans. The available antibiotic treatment options for combating CRKP ...
Optimization of linezolid dosing regimens for treatment of vancomycin-resistant enterococci infection
Background: Linezolid, an oxazolidinone antibiotic, is recommended for vancomycin-resistant enterococci (VRE). However, 100% free-drug concentration above the minimum inhibitory concentration (fT>MIC) and an area under the ...
Antimicrobials as single and combination therapy for colistin-resistant pseudomonas aeruginosa at a university hospital in Thailand
Global infections with colistin-resistant Pseudomonas aeruginosa (CoR-PA) are increasing; there are currently very few studies focused on the antimicrobial susceptibility of CoR-PA isolates, and none from Thailand. Here, ...
Does vancomycin resistance increase mortality? clinical outcomes and predictive factors for mortality in patients with enterococcus faecium infections
The prevalence of enterococcal infection, especially E. faecium, is increasing, and the issue of the impact of vancomycin resistance on clinical outcomes is controversial. This study aimed to investigate the clinical ...