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Controlled release of felodipine from 3D-printed tablets with constant surface area: Influence of surface geometry
In this study, 3D-printed tablets with a constant surface area were designed and fabricated using polylactic acid (PLA) in the outer compartment and polyvinyl alcohol and felodipine (FDP) in the inner compartment. The ...
Optimized Taste-Masked Microparticles for Orally Disintegrating Tablets as a Promising Dosage Form for Alzheimer’s Disease Patients
The objective of this research was to optimize the tasted-masked microparticles for orally disintegrating tablets containing donepezil hydrochloride using quality risk assessment and design of experiment approaches. The ...
Effect of a superdisintegrant on disintegration of orally disintegrating tablets determined by simulated wetting test and in vitrodisintegration test
The disintegration time is critical for characterizing orally disintegrating tablets (ODTs), according to regulatory standards. The current study aimed to assess the effect of superdisintegrants such as sodium starch ...
Salt formation, stability study and tablet formulation of mefenamic acid with improved drug dissolution
Mefenamic acid is characterized by a low oral bioavailability due to its slow dissolution and absorption. The purpose of this study was to investigate the effect of salt formation on dissolution of mefenamic acid and its ...
Impact of drug loading method on drug release from 3D-printed tablets made from filaments fabricated by hot-melt extrusion and impregnation processes
The purpose of this study was to investigate the impact of the drug loading method on drug release from 3D-printed tablets. Filaments comprising a poorly water-soluble model drug, indomethacin (IND), and a polymer, polyvinyl ...