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Feasibility of chitosan-based nanoparticles approach for intranasal immunisation of live attenuated Japanese encephalitis vaccine
Intranasal (IN) administration, a non-invasive route, is explored to overcome the limitations of conventional subcutaneous (SC) injection for Japanese encephalitis (JE) immunisation. Mucoadhesive nanoparticles (NPs) are ...
Doxorubicin-loaded N-naphthyl-N,O-succinyl chitosan micelles for colon cancer treatment
Doxorubicin (Dox) is one of the effective treatments in many types of cancer, such as breast cancer and ovarian cancer. However, the clinical settings of this drug are limited by its low therapeutic efficiency and high ...
Preparation and evaluation of 6-Maleimidohexanoic acid grafted chitosan nanoparticles as a novel carrier for intranasal protein delivery
In this study, 6-maleimidohexanoic acid grafted chitosan nanoparticles (MHA-CS NPs) were prepared and evaluated the efficiency of intranasal protein delivery as compared with well-known chitosan nanoparticles (CS NPs). ...
Effects of silymarin-loaded amphiphilic chitosan polymeric micelles on the renal toxicity and anticancer activity of cisplatin
This research aimed to evaluate the effects of silymarin (SM)-loaded polymeric micelles (PMs) on the renal toxicity and anticancer activity of cisplatin. Amphiphilic chitosan derivatives were employed to develop SM-loaded ...
Dual-Charge Nanofiber Mats Made of Chitosan(CS)/Poly(Vinyl Alcohol) (PVA) and Poly-(Acrylic Acid-Co-Maleic Acid) (PAMA)/PVA
Nanofibers have been widely used for tissue engineering. Using charged polymers for the preparation of nanofibers can be useful for the loading of substances or macromolecules. Dual charge nanofiber mats are expected to ...
Folate-Functionalized Amphiphilic Chitosan Polymeric Micelles Containing Andrographolide Analogue (3A.1) for Colorectal Cancer
A site-specific drug delivery system of anticancer agents has been delveloped to enhance the therapeutic efficacy and reduce toxicity to the normal tissue. Semi-synthetic andrographolide analogue 3A.1 (19-tert-butyldiphe ...
Fabrication and characterization of andrographolide analogue (3A.1) nanosuspensions stabilized by amphiphilic chitosan derivatives for colorectal cancer therapy
Recently, 19-tert-butyldiphenylsilyl-8,17-epoxy andrographolide (3A.1) is an andrographolide analogue which was a promising chemotherapeutic agent against some types of cancer. However, this compound has an extremely low ...
Chitosan capped-gold nanoparticles as skin penetration enhancer for small molecules: A study in porcine skin
Skin is considered one of the most convenient sites for drug administration. The present study evaluated the effect of gold nanoparticles stabilized by chitosan (CS-AuNPs) and citrate ions (Ci-AuNPs) on skin permeation of ...