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พอลิเมอริกไมเซลล์สำหรับนำส่งยาสู่เนื้องอกเป้าหมาย
ปัจจุบันการรักษามะเร็งด้วยการใช้ยาเคมีบำบัดยังพบปัญหาต่าง ๆ เช่น ยาเคมีบำบัดไม่สามารถทำลายเซลล์มะเร็งอย่างจำเพาะแต่ทำลายเซลล์ปกติของร่างกายได้ และเกิดปัญหาการดื้อยาด้วย พอลิเมอริกไมเซลล์เป็นระบบห่อหุ้มนำส่งยา ที่มีขนาดอน ...
Effects of crosslinking temperature and time on the properties of POLY-(ACRYLIC ACID-CO-MALEIC ACID) (PAMA) /POLY (VINYL ALCOHOL) (PVA) electrospun nanofiber mats
The advantage of thermal crosslinking of nanofiber mats is that the nanofibers will not be easily dissolved and be able to adsorb drug substance when they are soaked in drug solution. Due to the simplicity and environmental ...
Effects of silymarin-loaded amphiphilic chitosan polymeric micelles on the renal toxicity and anticancer activity of cisplatin
This research aimed to evaluate the effects of silymarin (SM)-loaded polymeric micelles (PMs) on the renal toxicity and anticancer activity of cisplatin. Amphiphilic chitosan derivatives were employed to develop SM-loaded ...
Dual-Charge Nanofiber Mats Made of Chitosan(CS)/Poly(Vinyl Alcohol) (PVA) and Poly-(Acrylic Acid-Co-Maleic Acid) (PAMA)/PVA
Nanofibers have been widely used for tissue engineering. Using charged polymers for the preparation of nanofibers can be useful for the loading of substances or macromolecules. Dual charge nanofiber mats are expected to ...
Optimization of Boesenbergia rotunda Extract-Loaded Polyvinyl Alcohol Hydrogel Wound Dressing by Box-Behnken Design
The objective of this study was to optimize fabrication variables that affected desirable properties of dressings. Boesenbergia rotunda extract incorporated PVA hydrogels for wound dressings were fabricated by freeze-thaw ...
Folate-Functionalized Amphiphilic Chitosan Polymeric Micelles Containing Andrographolide Analogue (3A.1) for Colorectal Cancer
A site-specific drug delivery system of anticancer agents has been delveloped to enhance the therapeutic efficacy and reduce toxicity to the normal tissue. Semi-synthetic andrographolide analogue 3A.1 (19-tert-butyldiphe ...
A novel plier-like gemini cationic niosome for nucleic acid delivery
This study aimed to develop a novel cationic niosome formulation from a novel plier-like cationic lipid A (PCL-A) with Span 20 and cholesterol (Chol). The niosomes were prepared by a thin film hydration method followed by ...
Fabrication and characterization of andrographolide analogue (3A.1) nanosuspensions stabilized by amphiphilic chitosan derivatives for colorectal cancer therapy
Recently, 19-tert-butyldiphenylsilyl-8,17-epoxy andrographolide (3A.1) is an andrographolide analogue which was a promising chemotherapeutic agent against some types of cancer. However, this compound has an extremely low ...
PEGylated Plier-Like Cationic Niosomes on Gene Delivery in HeLa Cells
Lipid-based formulations have been used as a widespread carrier to improve gene delivery. Niosomes, one type of lipid-based vesicular systems are produced from non-ionic surfactants which are generally inexpensive and ...