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Treatment outcomes and their predictive factors in patients withEnterobacter spp., Serratia spp.,Citrobacter spp., Providencia spp., I-indole-positive Proteus spp., andMorganella spp, bloodstream infection
The present study examined the treatment outcomes and factors related to mortality in patients with Enterobacter spp., Serratia spp., Citrobacter spp., Providencia spp., I-indole-positive Proteus spp., and Morganella spp. ...
Optimal tigecycline dosage regimens in patients infected with carbapenem-resistant Enterobacteriaceae
We aimed to evaluate the minimum inhibitory concentration (MIC) values of tigecycline for carbapenem-resistant Enterobacteriaceae (CRE) and to identify a potential regimen for achieving target values of the area under the ...
The prevalence of colistin-resistant Gram-negative bacteria isolated from hospitalized patients with bacteremia
This study sought to investigate the prevalence of colistin-resistant Gram-negative bacteria (CoR-GNB) among Pseudomonas aeruginosa, Acinetobacter baumannii, Escherichia coli, and Klebsiella pneumoniae isolated from patients ...
A comparison between conventional and stratified antibiograms for antibiotic empirical therapy among the most bacterial pathogens
Antibiogramsprovideimportant data regarding antimicrobial selection duringempirical therapy and formonitoringyearly trends in antimicrobial resistance in healthcare settings. Antibiograms tailored to hospital location ...
Is Early Monitoring Better? Impact of Early Vancomycin Exposure on Treatment Outcomes and Nephrotoxicity in Patients with Methicillin-Resistant Staphylococcus aureus Infections
Optimal early vancomycin target exposure remains controversial. To clarify the therapeutic exposure range, we investigated the association between vancomycin exposure and treatment outcomes or nephrotoxicity in patients ...
The susceptibility of penicillin, ceftriaxone, and cefotaxime against Streptococcus pneumoniae isolated from patients with invasive pneumococcal diseases at a teaching hospital in Thailand
Objective: Pneumococcal disease is a severe invasive infection causing morbidity and death, so the appropriate antimicrobials are greatly important. We aimed to determine the minimum inhibitory concentration (MIC) of ...
Vancomycin area under the curve and pharmacokinetic parameters during the first 24 Hours of treatment in critically ill patients using bayesian forecasting
Background
Currently, the achievement of the target area under the curve (AUC)/minimum inhibitory concentration ratio during the first 24 - 48 h of treatment is associated with reduced 30-day mortality and greater ...
Mono sulfamethoxazole/trimethoprim and Vancomycin combination antimicrobial zctivity against methicillin-resistant Staphylococcus aureus
Activity of trimethoprim/sulfamethoxazole (SXT) alone or in combination with vancomycin (VAN) was evaluated against methicillin-resistant Staphylococcus aureus (MRSA) from 26 clinical isolates from patients admitted to Hua ...
Vancomycin-resistant enterococcal infection in a Thai university hospital: clinical characteristics, treatment outcomes, and synergistic effect
Purpose: The incidence of infections with vancomycin-resistant enterococci (VRE) is increasing, with associated high mortality rates and limited therapeutic choices. We investigated the clinical characteristics and treatment ...
Identification of blaOXA23 and blaNDM1 from Carbapenem- resistant Acinetobacter baumannii at a Private Hospital in Thailand
OBJECTIVES: This study aimed to detect carbapenemase genes and their clonal relationships among carbapenem-resistant Acinetobacter baumannii (CRAB) clinical isolates.
MATERIAL AND METHODS: Fifteen CRAB isolates were ...
Optimizing the dosing regimens of tigecycline against vancomycin- resistant enterococci in the treatment of intra-abdominal and skin and soft tissue infections
Tigecycline was previously considered to have activity against vancomycin-resistant Enterococcus (VRE) isolates, but the optimal dose was not clarified. Thus, this study assessed the in vitro activity of tigecycline against ...
Prevalence of causative bacteria and clinical outcomes among patients with meningitis at a regional central hospital in Thailand
This study aimed to identify causative bacteria and to investigate the outcomes of treatment and the appropriate empirical regimen among patients with bacterial meningitis. Patients with bacterial meningitis admitted at ...
Colistin plus sulbactam or fosfomycin against carbapenem-resistant acinetobacter baumannii: improved efficacy or decreased risk of nephrotoxicity?
Background
Acinetobacter baumannii has been recognized as a cause of nosocomial infection. To date, polymyxins, the last-resort therapeutic agents for carbapenem-resistant A. baumannii (CRAB). Thus, the small number of ...
The Synergistic activity and optimizing doses of tigecycline in combination with aminoglycosides against clinical carbapenem-resistant klebsiella pneumoniae isolates
Carbapenem-resistant Enterobacteriaceae (CRE), especially carbapenem-resistant Klebsiella pneumoniae (CRKP), are among the largest pathogenic threats to humans. The available antibiotic treatment options for combating CRKP ...
The Potential use of ceftazidime-avibactam against carbapenem resistant klebsiella pneumoniae clinical isolates harboring different carbapenemase types in a Thai University Hospital
Purpose: MBL and OXA-48 genes in carbapenem-resistant Enterobacterales (CRE) have emerged as a major public health problem worldwide, including Thailand. Due to the lack of susceptibility data and dosing regimens of ...
Impact of pharmacist-led implementation of a community hospital-based outpatient parenteral antimicrobial therapy on clinical outcomes in Thailand
Few studies have analyzed community hospital-based parenteral anti-infective therapy (CohPAT). We aimed to assess the clinical impact of a pharmacist-led implementation of a clinical practice guideline (CPG) for CohPAT, ...
The First report of a methicillin-resistant staphylococcus aureus isolate harboring type IV SCCmec in Thailand
Methicillin-resistant Staphylococcus aureus (MRSA) is mostly found in Thailand in the hospital as a nosocomial pathogen. This study aimed to report the genetic characterization of a clinical community-acquired MRSA (CA-MRSA) ...
Clinical Impact of Vancomycin Treatment in Ampicillin-Susceptible Enterococci Bloodstream Infections
Enterococci are major causes of bacteremia. Although the mortality rate of ampicillin- susceptible enterococci (ASE) bloodstream infections (BSI) is lower, compared with that of ampicillin-resistant enterococci BSI, the ...
Optimization of linezolid dosing regimens for treatment of vancomycin-resistant enterococci infection
Background: Linezolid, an oxazolidinone antibiotic, is recommended for vancomycin-resistant enterococci (VRE). However, 100% free-drug concentration above the minimum inhibitory concentration (fT>MIC) and an area under the ...
Antimicrobial activity profiles and potential antimicrobial regimens against carbapenem-resistant enterobacterales isolated from multi-centers in Western Thailand
The spread of carbapenem-resistant Enterobacterales (CRE) constitutes a global health burden. Antimicrobial susceptibility and types of carbapenemase differ by geographic region. This study aimed to (1) examine the minimum ...