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Now showing items 11-20 of 22
A novel plier-like gemini cationic niosome for nucleic acid delivery
This study aimed to develop a novel cationic niosome formulation from a novel plier-like cationic lipid A (PCL-A) with Span 20 and cholesterol (Chol). The niosomes were prepared by a thin film hydration method followed by ...
Fabrication and characterization of andrographolide analogue (3A.1) nanosuspensions stabilized by amphiphilic chitosan derivatives for colorectal cancer therapy
Recently, 19-tert-butyldiphenylsilyl-8,17-epoxy andrographolide (3A.1) is an andrographolide analogue which was a promising chemotherapeutic agent against some types of cancer. However, this compound has an extremely low ...
PEGylated Plier-Like Cationic Niosomes on Gene Delivery in HeLa Cells
Lipid-based formulations have been used as a widespread carrier to improve gene delivery. Niosomes, one type of lipid-based vesicular systems are produced from non-ionic surfactants which are generally inexpensive and ...
Chitosan capped-gold nanoparticles as skin penetration enhancer for small molecules: A study in porcine skin
Skin is considered one of the most convenient sites for drug administration. The present study evaluated the effect of gold nanoparticles stabilized by chitosan (CS-AuNPs) and citrate ions (Ci-AuNPs) on skin permeation of ...
Development and evaluation of p-chlorophenyl benzyl ether-loaded microemulsions for transdermal delivery
p-Chlorophenyl benzyl ether (CBE) has been reported to be a new skin brightening agent. Because of its strong inhibitory effect on tyrosinase and its high safety, CBE was selected as a model antityrosinase compound in ...
Development of floating 3D-printed devices for carvedilol tablet
A floating drug delivery device is one type of gastro-retentive drug delivery system (GRDDS). Carvedilol (CAR) is poorly soluble in alkaline pH (intestinal environment) and has good solubility in the acidic pH (stomach ...
Fabrication of floating capsule-in- 3D-printed devices as gastro-retentive delivery systems of amoxicillin
Gastro-retentive drug delivery systems (GRDDS) provide prolonged drug release in the stomach for the treatment of some diseases located in the gastric area, and can improve patient compliance by reducing the required dosing ...
Feasibility of chitosan-based nanoparticles approach for intranasal immunisation of live attenuated Japanese encephalitis vaccine
Intranasal (IN) administration, a non-invasive route, is explored to overcome the limitations of conventional subcutaneous (SC) injection for Japanese encephalitis (JE) immunisation. Mucoadhesive nanoparticles (NPs) are ...
Doxorubicin-loaded N-naphthyl-N,O-succinyl chitosan micelles for colon cancer treatment
Doxorubicin (Dox) is one of the effective treatments in many types of cancer, such as breast cancer and ovarian cancer. However, the clinical settings of this drug are limited by its low therapeutic efficiency and high ...
Design and Optimization of 3D-Printed Gastroretentive Floating Devices by Central Composite Design
This study aimed to optimize the size of capsule-shaped 3D-printed devices (CPD) using an experimental design by the response surface methodology to provide a gastroretentive drug delivery system (GRDDS) with optimal ...