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Three-dimensional (3D)-printed devices composed of hydrophilic cap and hydrophobic body for improving buoyancy and gastric retention of domperidone tablets
The aim of this study was to produce capsule-shaped floating devices (CFD) using a fused deposition modeling (FDM) three-dimensional (3D) printer, for controlling the release and gastric retention of domperidone (DOM) ...
Effect of hydrophobic tails of plier-like cationic lipids on nucleic acid delivery and intracellular trafficking
In the optimization of transfection efficacy, one of the crucial barriers to effective gene delivery is in fact the intracellular trafficking of nucleic acids, besides the first and the last steps of gene transfer, i.e., ...
Fabrication, characterization and comparison of α-arbutin loaded dissolving and hydrogel forming microneedles
In this study, polyacrylic acid-co-maleic acid (PAMA) and polyvinyl alcohol (PVA) (1:4) were used to fabricate dissolving microneedles (DMNs) and hydrogel forming microneedles (HMNs) which incorporated α-arbutin. Αlpha-arbutin ...
In vitro and in vivo evaluation of amphiphilic chitosan derivatives for inhibition of organic cation transport function
This study explored the interaction of amphiphilic chitosan derivatives, N-benzyl-N,O-succinyl chitosan (BSCS), N-naphthyl-N,O-succinyl chitosan (NSCS) and N-octyl-N,O-succinyl chitosan (OSCS), with renal organic cation ...
Fabrication of floating capsule-in- 3D-printed devices as gastro-retentive delivery systems of amoxicillin
Gastro-retentive drug delivery systems (GRDDS) provide prolonged drug release in the stomach for the treatment of some diseases located in the gastric area, and can improve patient compliance by reducing the required dosing ...
Fabrication of a Floating Device of Domperidone Tablets Using 3D-Printing Technologies
Gastro-retentive drug delivery systems (GRDDS) have been developed with the aim of prolonging drug release. In this study, floating device systems (FDS) were developed and incorporated with a domperidone tablet (Motilium-M®). ...
Preparation and evaluation of 6-Maleimidohexanoic acid grafted chitosan nanoparticles as a novel carrier for intranasal protein delivery
In this study, 6-maleimidohexanoic acid grafted chitosan nanoparticles (MHA-CS NPs) were prepared and evaluated the efficiency of intranasal protein delivery as compared with well-known chitosan nanoparticles (CS NPs). ...