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Three-dimensional (3D)-printed devices composed of hydrophilic cap and hydrophobic body for improving buoyancy and gastric retention of domperidone tablets
The aim of this study was to produce capsule-shaped floating devices (CFD) using a fused deposition modeling (FDM) three-dimensional (3D) printer, for controlling the release and gastric retention of domperidone (DOM) ...
Fabrication of a novel high-density three-dimensional (3D)-printed device for domperidone tablets
In conventional high-density tablets, a large amount of high-density material must be directly added to the tablets. Therefore, it may lead to undesired tablet properties. The aim of this study was to develop novel ...
Chitosan capped-gold nanoparticles as skin penetration enhancer for small molecules: A study in porcine skin
Skin is considered one of the most convenient sites for drug administration. The present study evaluated the effect of gold nanoparticles stabilized by chitosan (CS-AuNPs) and citrate ions (Ci-AuNPs) on skin permeation of ...
Development and evaluation of p-chlorophenyl benzyl ether-loaded microemulsions for transdermal delivery
p-Chlorophenyl benzyl ether (CBE) has been reported to be a new skin brightening agent. Because of its strong inhibitory effect on tyrosinase and its high safety, CBE was selected as a model antityrosinase compound in ...
Development of floating 3D-printed devices for carvedilol tablet
A floating drug delivery device is one type of gastro-retentive drug delivery system (GRDDS). Carvedilol (CAR) is poorly soluble in alkaline pH (intestinal environment) and has good solubility in the acidic pH (stomach ...
Fabrication of floating capsule-in- 3D-printed devices as gastro-retentive delivery systems of amoxicillin
Gastro-retentive drug delivery systems (GRDDS) provide prolonged drug release in the stomach for the treatment of some diseases located in the gastric area, and can improve patient compliance by reducing the required dosing ...
Feasibility of chitosan-based nanoparticles approach for intranasal immunisation of live attenuated Japanese encephalitis vaccine
Intranasal (IN) administration, a non-invasive route, is explored to overcome the limitations of conventional subcutaneous (SC) injection for Japanese encephalitis (JE) immunisation. Mucoadhesive nanoparticles (NPs) are ...
Doxorubicin-loaded N-naphthyl-N,O-succinyl chitosan micelles for colon cancer treatment
Doxorubicin (Dox) is one of the effective treatments in many types of cancer, such as breast cancer and ovarian cancer. However, the clinical settings of this drug are limited by its low therapeutic efficiency and high ...
Design and Optimization of 3D-Printed Gastroretentive Floating Devices by Central Composite Design
This study aimed to optimize the size of capsule-shaped 3D-printed devices (CPD) using an experimental design by the response surface methodology to provide a gastroretentive drug delivery system (GRDDS) with optimal ...
Fabrication of a Floating Device of Domperidone Tablets Using 3D-Printing Technologies
Gastro-retentive drug delivery systems (GRDDS) have been developed with the aim of prolonging drug release. In this study, floating device systems (FDS) were developed and incorporated with a domperidone tablet (Motilium-M®). ...