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Three-dimensional (3D)-printed devices composed of hydrophilic cap and hydrophobic body for improving buoyancy and gastric retention of domperidone tablets
The aim of this study was to produce capsule-shaped floating devices (CFD) using a fused deposition modeling (FDM) three-dimensional (3D) printer, for controlling the release and gastric retention of domperidone (DOM) ...
Fabrication of a novel high-density three-dimensional (3D)-printed device for domperidone tablets
In conventional high-density tablets, a large amount of high-density material must be directly added to the tablets. Therefore, it may lead to undesired tablet properties. The aim of this study was to develop novel ...
Effect of hydrophobic tails of plier-like cationic lipids on nucleic acid delivery and intracellular trafficking
In the optimization of transfection efficacy, one of the crucial barriers to effective gene delivery is in fact the intracellular trafficking of nucleic acids, besides the first and the last steps of gene transfer, i.e., ...
Fabrication, characterization and comparison of α-arbutin loaded dissolving and hydrogel forming microneedles
In this study, polyacrylic acid-co-maleic acid (PAMA) and polyvinyl alcohol (PVA) (1:4) were used to fabricate dissolving microneedles (DMNs) and hydrogel forming microneedles (HMNs) which incorporated α-arbutin. Αlpha-arbutin ...
In vitro and in vivo evaluation of amphiphilic chitosan derivatives for inhibition of organic cation transport function
This study explored the interaction of amphiphilic chitosan derivatives, N-benzyl-N,O-succinyl chitosan (BSCS), N-naphthyl-N,O-succinyl chitosan (NSCS) and N-octyl-N,O-succinyl chitosan (OSCS), with renal organic cation ...
Effects of crosslinking temperature and time on the properties of POLY-(ACRYLIC ACID-CO-MALEIC ACID) (PAMA) /POLY (VINYL ALCOHOL) (PVA) electrospun nanofiber mats
The advantage of thermal crosslinking of nanofiber mats is that the nanofibers will not be easily dissolved and be able to adsorb drug substance when they are soaked in drug solution. Due to the simplicity and environmental ...
Effects of silymarin-loaded amphiphilic chitosan polymeric micelles on the renal toxicity and anticancer activity of cisplatin
This research aimed to evaluate the effects of silymarin (SM)-loaded polymeric micelles (PMs) on the renal toxicity and anticancer activity of cisplatin. Amphiphilic chitosan derivatives were employed to develop SM-loaded ...
Dual-Charge Nanofiber Mats Made of Chitosan(CS)/Poly(Vinyl Alcohol) (PVA) and Poly-(Acrylic Acid-Co-Maleic Acid) (PAMA)/PVA
Nanofibers have been widely used for tissue engineering. Using charged polymers for the preparation of nanofibers can be useful for the loading of substances or macromolecules. Dual charge nanofiber mats are expected to ...
Optimization of Boesenbergia rotunda Extract-Loaded Polyvinyl Alcohol Hydrogel Wound Dressing by Box-Behnken Design
The objective of this study was to optimize fabrication variables that affected desirable properties of dressings. Boesenbergia rotunda extract incorporated PVA hydrogels for wound dressings were fabricated by freeze-thaw ...
Folate-Functionalized Amphiphilic Chitosan Polymeric Micelles Containing Andrographolide Analogue (3A.1) for Colorectal Cancer
A site-specific drug delivery system of anticancer agents has been delveloped to enhance the therapeutic efficacy and reduce toxicity to the normal tissue. Semi-synthetic andrographolide analogue 3A.1 (19-tert-butyldiphe ...