Browsing by Author "Prasopchai Patrojanasophon"
Now showing items 1-20 of 35
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Catechol-modified chitosan/hyaluronic acid nanoparticles as a new avenue for local delivery of doxorubicin to oral cancer cells
Collection: Pride & Awards 2020 - PHARM / ผลงานโดดเด่นปีการศึกษา 2563 - ภศ.Type: Article(Colloids and Surfaces B: Biointerfaces, 2020-12)Local administration of chemotherapeutic drugs to a tumor site in the oral cavity can provide high drug concentrations in the tumor area and reduce systemic side effects. In this work, catechol (Cat)-modified chitosan/hyaluronic ... -
Chitosan capped-gold nanoparticles as skin penetration enhancer for small molecules: A study in porcine skin
Collection: Article - Pharmaceutical Technology / บทความทางวิชาการ - เทคโนโลยีเภสัชกรรมType: Article(Elsevier, 2023)Skin is considered one of the most convenient sites for drug administration. The present study evaluated the effect of gold nanoparticles stabilized by chitosan (CS-AuNPs) and citrate ions (Ci-AuNPs) on skin permeation of ... -
Design and Optimization of 3D-Printed Gastroretentive Floating Devices by Central Composite Design
Collection: Article - Pharmaceutical Technology / บทความทางวิชาการ - เทคโนโลยีเภสัชกรรมType: Article(American Association of Pharmaceutical Scientists, 2021)This study aimed to optimize the size of capsule-shaped 3D-printed devices (CPD) using an experimental design by the response surface methodology to provide a gastroretentive drug delivery system (GRDDS) with optimal ... -
Development and evaluation of hydroxypropyl methylcellulose patches containing clindamycin for topical application
Collection: Article - Industrial Pharmacy / บทความ - เภสัชกรรมอุตสาหการType: Article(Trans Tech Publications Ltd., 2019)Clindamycin (CM) is the one of antibacterial drugs that can be used to treat acne vulgaris. The commercial products in form of solutions, creams, and gels cannot provide the exact amount of the drug and constant drug ... -
Development and evaluation of p-chlorophenyl benzyl ether-loaded microemulsions for transdermal delivery
Collection: Article - Pharmaceutical Technology / บทความทางวิชาการ - เทคโนโลยีเภสัชกรรมType: Article(Research Institute, Rangsit University, 2021)p-Chlorophenyl benzyl ether (CBE) has been reported to be a new skin brightening agent. Because of its strong inhibitory effect on tyrosinase and its high safety, CBE was selected as a model antityrosinase compound in ... -
Development of mucoadhesive chitosan-Iodoacetamide buccal tablets for local delivery of dextromethorphan
Collection: Article - Industrial Pharmacy / บทความ - เภสัชกรรมอุตสาหการType: Article(Office of Research Administration, Office of the University Chiang Mai University, 2023)This study aimed to synthesize a chitosan (CHI) derivative, chitosan-iodoacetamide (CHI-IA), with enhanced mucoadhesive properties and develop buccal mucoadhesive tablets of CHI-IA for local delivery of dextromethorphan ... -
Development of nano-based drug-delivering carriers for colorectal and breast cancer targeting
Collection: Theses (Ph.D) - Pharmaceutical Technology / ดุษฎีนิพนธ์ - เทคโนโลยีเภสัชกรรมType: Thesis(Silpakorn University, 4/7/2023)This study aimed to develop three types of nanocarriers for targeted delivery of chemotherapeutic drugs to colorectal and breast cancers: Polyethylene glycol diacrylate/polyacrylic acid nanoparticles (PEGDA/AA NPs), ... -
Doxorubicin-loaded N-naphthyl-N,O-succinyl chitosan micelles for colon cancer treatment
Collection: Article - Pharmaceutical Technology / บทความทางวิชาการ - เทคโนโลยีเภสัชกรรมType: Article(Silpakorn University, 2021)Doxorubicin (Dox) is one of the effective treatments in many types of cancer, such as breast cancer and ovarian cancer. However, the clinical settings of this drug are limited by its low therapeutic efficiency and high ... -
Dual-Charge Nanofiber Mats Made of Chitosan(CS)/Poly(Vinyl Alcohol) (PVA) and Poly-(Acrylic Acid-Co-Maleic Acid) (PAMA)/PVA
Collection: Article - Pharmaceutical Technology / บทความทางวิชาการ - เทคโนโลยีเภสัชกรรมType: Article(Trans Tech Publications Ltd, 2019)Nanofibers have been widely used for tissue engineering. Using charged polymers for the preparation of nanofibers can be useful for the loading of substances or macromolecules. Dual charge nanofiber mats are expected to ... -
Effect of hydrophobic tails of plier-like cationic lipids on nucleic acid delivery and intracellular trafficking
Collection: Article - Pharmaceutical Technology / บทความทางวิชาการ - เทคโนโลยีเภสัชกรรมType: Article(Elsevier, 2020)In the optimization of transfection efficacy, one of the crucial barriers to effective gene delivery is in fact the intracellular trafficking of nucleic acids, besides the first and the last steps of gene transfer, i.e., ... -
Effects of crosslinking temperature and time on the properties of POLY-(ACRYLIC ACID-CO-MALEIC ACID) (PAMA) /POLY (VINYL ALCOHOL) (PVA) electrospun nanofiber mats
Collection: Article - Pharmaceutical Technology / บทความทางวิชาการ - เทคโนโลยีเภสัชกรรมType: Article(Rangsit University, 2019)The advantage of thermal crosslinking of nanofiber mats is that the nanofibers will not be easily dissolved and be able to adsorb drug substance when they are soaked in drug solution. Due to the simplicity and environmental ... -
Effects of silymarin-loaded amphiphilic chitosan polymeric micelles on the renal toxicity and anticancer activity of cisplatin
Collection: Article - Pharmaceutical Technology / บทความทางวิชาการ - เทคโนโลยีเภสัชกรรมType: Article(Taylor & Francis, 2019)This research aimed to evaluate the effects of silymarin (SM)-loaded polymeric micelles (PMs) on the renal toxicity and anticancer activity of cisplatin. Amphiphilic chitosan derivatives were employed to develop SM-loaded ... -
Enhancement of transdermal delivery of resveratrol using Eudragit and polyvinyl pyrrolidone-based dissolving microneedle patches
Collection: Article - Industrial Pharmacy / บทความ - เภสัชกรรมอุตสาหการType: Article(Elsevier, 2021)Resveratrol is a natural phenol, which has lipophilic properties. Despite the interest of the pharmacological effects of resveratrol, its low bioavailability and poor solubility limit its use in pharmaceutical and cosmetic ... -
Fabrication and characterization of andrographolide analogue (3A.1) nanosuspensions stabilized by amphiphilic chitosan derivatives for colorectal cancer therapy
Collection: Article - Pharmaceutical Technology / บทความทางวิชาการ - เทคโนโลยีเภสัชกรรมType: Article(Elsevier, 2019)Recently, 19-tert-butyldiphenylsilyl-8,17-epoxy andrographolide (3A.1) is an andrographolide analogue which was a promising chemotherapeutic agent against some types of cancer. However, this compound has an extremely low ... -
Fabrication and evaluation of chlorhexidine gluconate-incorporated chitosan-poly (vinyl alcohol) hydrogel films for infected wounds
Collection: Article - Industrial Pharmacy / บทความ - เภสัชกรรมอุตสาหการType: Article(Faculty of Pharmacy, Silpakorn University, 2023)Antibacterial dressings play an essential role in wound repair and infection control. This study aimed to fabricate chlorhexidine gluconate (CHX)-loaded chitosan-based hydrogel films via a physical cross-linking approach. ... -
Fabrication of a Floating Device of Domperidone Tablets Using 3D-Printing Technologies
Collection: Article - Pharmaceutical Technology / บทความทางวิชาการ - เทคโนโลยีเภสัชกรรมType: Article(Trans Tech Publications Ltd, 2020)Gastro-retentive drug delivery systems (GRDDS) have been developed with the aim of prolonging drug release. In this study, floating device systems (FDS) were developed and incorporated with a domperidone tablet (Motilium-M®). ... -
Fabrication of a novel high-density three-dimensional (3D)-printed device for domperidone tablets
Collection: Article - Pharmaceutical Technology / บทความทางวิชาการ - เทคโนโลยีเภสัชกรรมType: Article(Faculty of Pharmacy, Silpakorn University, 2023)In conventional high-density tablets, a large amount of high-density material must be directly added to the tablets. Therefore, it may lead to undesired tablet properties. The aim of this study was to develop novel ... -
Fabrication of floating capsule-in- 3D-printed devices as gastro-retentive delivery systems of amoxicillin
Collection: Article - Pharmaceutical Technology / บทความทางวิชาการ - เทคโนโลยีเภสัชกรรมType: Article(Elsevier, 2020)Gastro-retentive drug delivery systems (GRDDS) provide prolonged drug release in the stomach for the treatment of some diseases located in the gastric area, and can improve patient compliance by reducing the required dosing ... -
Fabrication, characterization and comparison of α-arbutin loaded dissolving and hydrogel forming microneedles
Collection: Article - Pharmaceutical Technology / บทความทางวิชาการ - เทคโนโลยีเภสัชกรรมType: Article(Elsevier, 2020)In this study, polyacrylic acid-co-maleic acid (PAMA) and polyvinyl alcohol (PVA) (1:4) were used to fabricate dissolving microneedles (DMNs) and hydrogel forming microneedles (HMNs) which incorporated α-arbutin. Αlpha-arbutin ... -
Feasibility of chitosan-based nanoparticles approach for intranasal immunisation of live attenuated Japanese encephalitis vaccine
Collection: Article - Pharmaceutical Technology / บทความทางวิชาการ - เทคโนโลยีเภสัชกรรมType: Article(Elsevier, 2021)Intranasal (IN) administration, a non-invasive route, is explored to overcome the limitations of conventional subcutaneous (SC) injection for Japanese encephalitis (JE) immunisation. Mucoadhesive nanoparticles (NPs) are ...