Browsing by Author "ปราณีต โอปณะโสภิต"
Now showing items 1-6 of 6
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Development of alpha-arbutin and resveratrol-loaded dissolving microneedles for skin depigmentation
Collection: Theses (Ph.D) - Pharmaceutical Technology / ดุษฎีนิพนธ์ - เทคโนโลยีเภสัชกรรมType: Thesis(Silpakorn University, 18/6/2021)In this study, polymeric dissolving microneedles (DMNs) were developed to enhance the transdermal delivery of skin depigmentation agents into the melanocytes where melanin is synthesized. Alpha-arbutin (AA) is a well-known ... -
Development of andrographolide analogue (3A.1)-loaded nanocarriers and 3A.1 nanosuspensions for cancer therapy
Collection: Theses (Ph.D) - Pharmaceutical Technology / ดุษฎีนิพนธ์ - เทคโนโลยีเภสัชกรรมType: Thesis(Silpakorn University, 18/6/2021)In this study, 19-tert-butylsilyldiphenyl-8,17-epoxy andrographolide (3A.1)-loaded nanocarriers and 3A.1 nanosuspensions were developed for improving its aqueous solubility and antitumor efficacy. First, the pH-sensitive ... -
DEVELOPMENT OF PLIER-LIKE CATIONIC NIOSOMES FOR GENE DELIVERY AGAINST BREAST CANCER CELLS
Collection: Theses (Ph.D) - Pharmaceutical Technology / ดุษฎีนิพนธ์ - เทคโนโลยีเภสัชกรรมType: Thesis(Silpakorn University, 18/6/2021)In this study, novelly synthesized plier-like cationic lipids (PCLs, i.e., PCL-A, -B and -C) were used to formulate plier-like cationic niosomes (PCNs) for nucleic acid delivery. The molar ratio of PCL-A was primarily ... -
Development of protein extracts -loaded nanocarriers combination with microspicules for transdermal delivery
Collection: Theses (Ph.D) - Pharmaceutical Technology / ดุษฎีนิพนธ์ - เทคโนโลยีเภสัชกรรมType: Thesis(Silpakorn University, 1/7/2022)Proteins extracted from natural products are hydrophilic macromolecules which limited the ability to passively penetrate through the skin. The combination of penetration enhancing techniques such as nanocarriers and sponge ... -
Interaction of pharmaceutical excipients and chitosan derivatives with organic cation transporters and potential for the prevention of cisplatin-induced nephrotoxicity
Collection: Theses (Ph.D) - Pharmaceutical Technology / ดุษฎีนิพนธ์ - เทคโนโลยีเภสัชกรรมType: Thesis(Silpakorn University, 12/7/2019)Pharmaceutical excipients are pharmacologically inert, however, they have been reported to have several biological effects. They showed an effects on several transport function of uptake and efflux drug transporters, these ... -
Three-dimensional (3D)-printed devices composed of hydrophilic cap and hydrophobic body for improving buoyancy and gastric retention of domperidone tablets
Collection: Pride & Awards 2020 - PHARM / ผลงานโดดเด่นปีการศึกษา 2563 - ภศ.Type: Article(European Journal of Pharmaceutical Sciences, 2020-12-01)The aim of this study was to produce capsule-shaped floating devices (CFD) using a fused deposition modeling (FDM) three-dimensional (3D) printer, for controlling the release and gastric retention of domperidone (DOM) ...